Multiple sclerosis - ethiology and pathogenesis

Multiple sclerosis - ethiology and patogenesis

Multiple sclerosis (MS) is a chronic neurologic disease with pathological changes in the brain involving demyelination. The pathogenesis of MS is unknown, but it is clear that environmental factors are of major importance for its development. These factors include in particular Epstein Barr virus (EBV), but also human herpesvirus 6A/B, endogenous retroviruses, low level of vitamin D3 and smoking. Our laboratory has a special interest in the mechanisms by which EBV and HHV-6A/B may cause the disease. Ongoing projects include:

  • Vitamin D and immunoregulatory cells in MS
  • EBV and B cells in MS
  • Immune response to EBV in MS
  • HHV-6A/B and cell death mechanisms