The role of CD46 for host susceptibility to infections by bacteria and viruses

Project supported by The Danish Council for Independent Research 2015 – 2017

CD46 in infection and immunity

CD46 is a transmembrane protein of importance for infection by a number of microorganisms. It is expressed under genetic control in four isoforms, but it is unknown whether this affects susceptibility to infections and how microorganisms may signal through the receptor to influence the conditions for infection.

We will examine this by studying the interaction between microorganisms and the various isoforms of CD46 and combine this knowledge with results obtained by sequencing CD46 and investigating CD46 SNPs.

Finally, we will examine pathogenic and non-pathogenic microorganisms’ signaling capacity through CD46 isoforms. These analyses may disclose an important and unappreciated host susceptibility element to infections.